PROSITE documentation PDOC51020
Spondin domain profile


The spondin domain is a ~200 amino acid module containing two conserved motifs, FS1 and FS2, that is shared by the vertebrate and invertebrate F-spondin family of proteins, which includes both F-spondin and M-spondin/Mindin (renamed Spon1 and Spon2 respectively). The spondin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1) (see <PDOC50092>), the reelin domain (see <PDOC51019>), the fibronectin type III domain (see <PDOC50853>) or the Kunitz trypsin protease inhibitor domain (see <PDOC00252>). The function of the spondin domain is not known but it might interact with other factors [1,2,3].

The profile we developed covers the entire spondin domain.

Last update:

September 2004 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SPONDIN, PS51020; Spondin domain profile  (MATRIX)


1AuthorsHigashijima S. Nose A. Eguchi G. Hotta Y. Okamoto H.
TitleMindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis.
SourceDev. Biol. 192:211-227(1997).
PubMed ID9441663

2AuthorsFeinstein Y. Borrell V. Garcia C. Burstyn-Cohen T. Tzarfaty V. Frumkin A. Nose A. Okamoto H. Higashijima S. Soriano E. Klar A.
TitleF-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons.
SourceDevelopment 126:3637-3648(1999).
PubMed ID10409509

3AuthorsFeinstein Y. Klar A.
TitleThe neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities.
SourceInt. J. Biochem. Cell Biol. 36:975-980(2004).
PubMed ID15094111

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