PROSITE documentation PDOC51020Spondin domain profile
The spondin domain is a ~200 amino acid module containing two conserved motifs, FS1 and FS2, that is shared by the vertebrate and invertebrate F-spondin family of proteins, which includes both F-spondin and M-spondin/Mindin (renamed Spon1 and Spon2 respectively). The spondin domain is found in association with other modules, such as the thrombospondin type I repeat (TSP1) (see <PDOC50092>), the reelin domain (see <PDOC51019>), the fibronectin type III domain (see <PDOC50853>) or the Kunitz trypsin protease inhibitor domain (see <PDOC00252>). The function of the spondin domain is not known but it might interact with other factors [1,2,3].
The profile we developed covers the entire spondin domain.
Last update:September 2004 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Higashijima S. Nose A. Eguchi G. Hotta Y. Okamoto H. |
| Title | Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis. | |
| Source | Dev. Biol. 192:211-227(1997). | |
| PubMed ID | 9441663 |
| 2 | Authors | Feinstein Y. Borrell V. Garcia C. Burstyn-Cohen T. Tzarfaty V. Frumkin A. Nose A. Okamoto H. Higashijima S. Soriano E. Klar A. |
| Title | F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. | |
| Source | Development 126:3637-3648(1999). | |
| PubMed ID | 10409509 |
| 3 | Authors | Feinstein Y. Klar A. |
| Title | The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities. | |
| Source | Int. J. Biochem. Cell Biol. 36:975-980(2004). | |
| PubMed ID | 15094111 | |
| DOI | 10.1016/j.biocel.2004.01.002 |
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