PROSITE documentation PDOC51039
Zinc finger AN1-type profile


This domain was first identified as a putative zinc finger found in the protein encoded by the Xenopus laevis An1 maternal mRNA [1]. The AN1-type zinc finger contains six conserved cysteines and two histidines that could potentially coordinate 2 zinc atoms.

The AN1-type zinc finger is frequently found associated with domains linked to the ubiquitination pathway, such as the A20-type zinc finger (see <PDOC51036>), the ubiquitin-like domain (see <PDOC00271>), or the UIM domain (see <PDOC50330>). The function of the AN1-type zinc finger is not yet known.

Some proteins known to contain an AN1-type zinc finger are listed below:

  • Ascidian posterior end mark 6 (pem-6) protein. Its mRNA is maternally expressed and localized in the posterior-vegetal cytoplasm of ascidian embryo [2].
  • Human AWP1 protein (associated with PRK1). Its gene is turned on early during embryogenesis and ubiquitously expressed [3].
  • Human immunoglobulin mu binding protein 2 (SMUBP-2). Mutations in the gene encoding SMUBP-2 cause spinal muscular atrophy with respiratory distress type 1 [4].

The profile we developed covers the whole AN1-type zinc finger.

Last update:

March 2021 / Profile revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_AN1, PS51039; Zinc finger AN1-type profile  (MATRIX)


1AuthorsLinnen J.M. Bailey C.P. Weeks D.L.
TitleTwo related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins.
SourceGene 128:181-188(1993).
PubMed ID8390387

2AuthorsSatou Y. Satoh N.
TitlePosterior end mark 2 (pem-2), pem-4, pem-5, and pem-6: maternal genes with localized mRNA in the ascidian embryo.
SourceDev. Biol. 192:467-481(1997).
PubMed ID9441682

3AuthorsDuan W. Sun B. Li T.W. Tan B.J. Lee M.K. Teo T.S.
TitleCloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo.
SourceGene 256:113-121(2000).
PubMed ID11054541

4AuthorsGrohmann K. Schuelke M. Diers A. Hoffmann K. Lucke B. Adams C. Bertini E. Leonhardt-Horti H. Muntoni F. Ouvrier R. Pfeufer A. Rossi R. Van Maldergem L. Wilmshurst J.M. Wienker T.F. Sendtner M. Rudnik-Schoneborn S. Zerres K. Hubner C.
TitleMutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1.
SourceNat. Genet. 29:75-77(2001).
PubMed ID11528396

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