PROSITE documentation PDOC51039Zinc finger AN1-type profile
This domain was first identified as a putative zinc finger found in the protein encoded by the Xenopus laevis An1 maternal mRNA [1]. The AN1-type zinc finger contains six conserved cysteines and two histidines that could potentially coordinate 2 zinc atoms.
The AN1-type zinc finger is frequently found associated with domains linked to the ubiquitination pathway, such as the A20-type zinc finger (see <PDOC51036>), the ubiquitin-like domain (see <PDOC00271>), or the UIM domain (see <PDOC50330>). The function of the AN1-type zinc finger is not yet known.
Some proteins known to contain an AN1-type zinc finger are listed below:
- Ascidian posterior end mark 6 (pem-6) protein. Its mRNA is maternally expressed and localized in the posterior-vegetal cytoplasm of ascidian embryo [2].
- Human AWP1 protein (associated with PRK1). Its gene is turned on early during embryogenesis and ubiquitously expressed [3].
- Human immunoglobulin mu binding protein 2 (SMUBP-2). Mutations in the gene encoding SMUBP-2 cause spinal muscular atrophy with respiratory distress type 1 [4].
The profile we developed covers the whole AN1-type zinc finger.
Last update:March 2021 / Profile revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Linnen J.M. Bailey C.P. Weeks D.L. |
| Title | Two related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins. | |
| Source | Gene 128:181-188(1993). | |
| PubMed ID | 8390387 |
| 2 | Authors | Satou Y. Satoh N. |
| Title | Posterior end mark 2 (pem-2), pem-4, pem-5, and pem-6: maternal genes with localized mRNA in the ascidian embryo. | |
| Source | Dev. Biol. 192:467-481(1997). | |
| PubMed ID | 9441682 | |
| DOI | 10.1006/dbio.1997.8730 |
| 3 | Authors | Duan W. Sun B. Li T.W. Tan B.J. Lee M.K. Teo T.S. |
| Title | Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. | |
| Source | Gene 256:113-121(2000). | |
| PubMed ID | 11054541 |
| 4 | Authors | Grohmann K. Schuelke M. Diers A. Hoffmann K. Lucke B. Adams C. Bertini E. Leonhardt-Horti H. Muntoni F. Ouvrier R. Pfeufer A. Rossi R. Van Maldergem L. Wilmshurst J.M. Wienker T.F. Sendtner M. Rudnik-Schoneborn S. Zerres K. Hubner C. |
| Title | Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1. | |
| Source | Nat. Genet. 29:75-77(2001). | |
| PubMed ID | 11528396 | |
| DOI | 10.1038/ng703 |
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