PROSITE documentation PDOC51927
Coronavirus membrane (CoV M) protein profile


Coronaviruses (CoVs) [E1] are a diverse group of enveloped, plus-stranded RNA viruses that infect humans and many animal species, in which they can cause respiratory, enteric, hepatic, central nervous system and neurological diseases of varying severity. The main CoV structural proteins are S (spike) (see <PDOC51923>), E (envelope) (see <PDOC51926>), M (membrane), and N (nucleocapsid), where S, E, and M are integral membrane proteins. The M protein of coronavirus plays a central role in virus assembly, turning cellular membranes into workshops where virus and host factors come together to make new virus particles. The CoV M protein, which functions as a homodimer, adapts a region of membrane for virus assembly and captures other structural proteins at the budding site. CoV M can adopt two conformations and membrane curvature is regulated by one M conformer. Elongated M protein is associated with rigidity, clusters of spikes and a relatively narrow range of membrane curvature. In contrast, compact M protein is associated with flexibility and low spike density [1].

The CoV M protein is characterized by a typical transmembrane (TM) region composed of three putative TM domains of 80 amino acid residues that account for about one third of the entire protein [2].

The profile we developed covers the entire CoV M protein.

Last update:

June 2020 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

COV_M, PS51927; Coronavirus membrane (Cov-M) protein profile  (MATRIX)


1AuthorsNeuman B.W. Kiss G. Kunding A.H. Bhella D. Baksh M.F. Connelly S. Droese B. Klaus J.P. Makino S. Sawicki S.G. Siddell S.G. Stamou D.G. Wilson I.A. Kuhn P. Buchmeier M.J.
TitleA structural analysis of M protein in coronavirus assembly and morphology.
SourceJ. Struct. Biol. 174:11-22(2011).
PubMed ID21130884

2AuthorsHu Y. Wen J. Tang L. Zhang H. Zhang X. Li Y. Wang J. Han Y. Li G. Shi J. Tian X. Jiang F. Zhao X. Wang J. Liu S. Zeng C. Wang J. Yang H.
TitleThe M protein of SARS-CoV: basic structural and immunological properties.
SourceGenomics Proteomics Bioinformatics 1:118-130(2003).
PubMed ID15626342


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