PROSITE documentation PDOC51938SUZ-C domain profile
Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. The centrosome consists of a pair of centrioles surrounded by a mass of pericentriolar material (PCM). In Caenorhabditis elegans, SZY-20 is a centrosome-associated RNA-binding protein that negatively regulates centrosome assembly. SZY-20 and its animal orthologs share three prominent blocks of conservation. The N-terminal block is a short element, which is found exclusively in orthologs of SZY-20. The second block in the center of the protein, termed the SUZ domain (see <PDOC51673>), is the strongest stretch of conservation and is enriched in charged residues. The third block, the SUZ-C domain, is at the extreme C-terminus and is defined by a characteristic pattern of two highly conserved glycines and one absolutely conserved proline. The SUZ and SUZ-C domains occur independently in proteins outside of the SZY-20 family. Many of these proteins contain known RNA-binding domains. The SUZ-C domain is a putative RNA-binding domain [1,2].
Some proteins known to contain a SUZ-C domain are listed below:
- Caenorhabditis elegans SZY-20,
- Animal orthologs of Caenorhabditis elegans SZY-20.
- Animal Cold shock domain-containing protein E1 (CSDE1), an RNA-binding protein.
- Vertebrate La-related protein 6 (LARP6) or Acheron (Achn), conserved member of the Lupus antigen family of RNA binding proteins.
The profile we developed covers the entire SUZ-C domain.
Last update:August 2020 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Song M.H. Aravind L. Mueller-Reichert T. O'Connell K.F. |
| Title | The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. | |
| Source | Dev. Cell. 15:901-912(2008). | |
| PubMed ID | 19081077 | |
| DOI | 10.1016/j.devcel.2008.09.018 |
| 2 | Authors | Stubenvoll M.D. Medley J.C. Irwin M. Song M.H. |
| Title | ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. | |
| Source | PLoS Genet. 12:E1006370-E1006370(2016). | |
| PubMed ID | 27689799 | |
| DOI | 10.1371/journal.pgen.1006370 |
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