PROSITE entry PS51073

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General information about the entry

Entry name [info]	RPEL
Accession [info]	PS51073
Entry type [info]	MATRIX
Date [info]	01-JAN-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51073
Associated ProRule [info]	PRU00401

Name and characterization of the entry

Description [info]

RPEL repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=26;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=24;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2495611; R2=0.0168148; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=432; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=319; N_SCORE=6.6; MODE=1; TEXT='RR';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='D';  M=-12, 23,-26, 28, 20,-29,-13, -2,-30,  9,-26,-21, 15,-10,  6,  3,  4, -2,-24,-33,-17, 13;
/M: SY='S';  M=  4, -7,-14, -8, -8,-12,-12,-13, -9,-10,-12,-10, -3,-16, -8, -8, 15, 12,  0,-29,-10, -8;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='E';  M= -5,  3,-24,  1, 14,-21,-17, -6,-16,  7,-15,-10,  5,-12,  7,  4,  0, -2,-16,-27,-14, 10;
/M: SY='R';  M=-14,-12,-27,-11,  2,-15,-23, -2,-13, 11, -6, -3, -7,-19,  2, 27,-12,-10, -9,-23, -8, -1;
/M: SY='K';  M=-11, -1,-30, -1,  9,-29,-20, -3,-30, 45,-29, -9,  1,-11, 10, 31,-10,-11,-21,-21, -8,  9;
/M: SY='L';  M= -9,-29,-22,-33,-24,  5,-32,-22, 30,-28, 35, 23,-26,-26,-19,-22,-25, -9, 19,-21, -1,-23;
/M: SY='A';  M= 12, -6,-17,-10, -3,-22, -3, -8,-16, -3,-18, -6, -1,-13,  6,  0, 12,  2,-11,-26,-16,  1;
/M: SY='H';  M= -9, -5,-23, -9, -6,-12,-12, 10,-10, -9, -9,  1,  1,-20,  6, -6, -4, -8,-11,-24, -5,  0;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='P';  M= -7,-14,-33, -8,  2,-28,-18,-13,-22,  2,-27,-16,-11, 46,  1,  0, -5, -7,-25,-27,-23, -2;
/M: SY='D';  M= -2,  7,-23,  9,  1,-25, -3,-13,-24, -8,-22,-18,  4,  4, -6,-13,  8,  8,-18,-31,-20, -3;
/M: SY='R';  M=-15,-13,-31,-11, -3,-21,-22, -1,-18, 14,-18, -8, -6,  2,  1, 28,-11,-10,-15,-23,-11, -5;
/M: SY='E';  M=  1,  2,-23,  5, 22,-25,-15, -6,-18,  3,-17,-10, -2, -8, 12, -3,  5, -4,-15,-28,-16, 17;
/M: SY='E';  M= -8,  9,-27, 16, 40,-30,-18, -1,-27,  6,-21,-17,  2, -4, 21, -1,  5, -2,-26,-30,-18, 31;
/M: SY='L';  M= -9,-30,-19,-30,-21,  9,-30,-21, 21,-29, 46, 19,-30,-30,-21,-20,-28, -9, 14,-21, -1,-21;
/M: SY='V';  M= -6,-20,-21,-20, -8, -6,-29,-21, 17,-13,  9,  6,-20,-21,-14,-15,-13, -6, 19,-26, -8,-12;
/M: SY='E';  M= -8, 16,-26, 14, 22,-28,-13,  1,-26, 13,-24,-16, 17,-10, 14,  8,  1, -7,-26,-30,-17, 18;
/M: SY='R';  M=-13, -5,-29, -7,  6,-26,-20, -2,-21, 28,-19,  1, -3,-14, 20, 31, -9,-10,-18,-20, -9, 12;
/M: SY='N';  M= -9,  8,-27,  2, -5,-26, 17, 18,-30, -5,-27,-14, 20,-19,  0, -4,  0,-13,-29,-28,-13, -3;
/M: SY='I';  M= -9,-30,-28,-39,-29,  1,-39,-29, 46,-29, 22, 19,-21,-21,-21,-29,-20, -9, 30,-21, -1,-29;
/M: SY='L';  M=-10,-29,-22,-32,-22,  7,-32,-21, 27,-29, 41, 23,-27,-27,-19,-22,-27,-10, 15,-20,  0,-22;
/M: SY='Q';  M=-12, -7,-31, -4, 11,-26,-21, 12,-19, -1,-16, -4, -7, 13, 17,  0, -8,-12,-25,-26,-11, 12;
/M: SY='E';  M= -2,-10,-24,-10,  6, -9,-17,-10,-13, -5,-13, -6,-10,  5, -1, -7, -2, -6,-13,-22,-12,  2;
/M: SY='B';  M= -7,  6,-20,  5,  1,-16,-15, -8,-11, -5, -8, -5,  4,-16, -4, -7,  2,  3, -8,-31,-13, -1;
/M: SY='E';  M= -5,  7,-23,  8, 10,-25,-12, -8,-23,  4,-26,-18,  8,  6,  1, -3,  9,  6,-20,-33,-19,  5;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	99 in 30 different sequences
Number of true positive hits	99 in 30 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	4
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	REPEAT
Feature description [info]	RPEL
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

30 sequences

MRTFA_HUMAN (Q969V6), MRTFA_MOUSE (Q8K4J6), MRTFA_XENLA (Q8AYC2),

MRTFB_HUMAN (Q9ULH7), MRTFB_MOUSE (P59759), MRTFB_XENLA (Q8AYC1), 
MYCD_HUMAN  (Q8IZQ8), MYCD_MOUSE  (Q8VIM5), MYCD_PIG(Q7YR76), 
MYCD_RAT(Q8R5I7), PHAR1_CHICK (Q801X6), PHAR1_HUMAN (Q9C0D0), 
PHAR1_MOUSE (Q2M3X8), PHAR1_RAT   (P62024), PHAR1_XENLA (Q6GLU8), 
PHAR2_HUMAN (O75167), PHAR2_RAT   (P62025), PHAR3_HUMAN (Q96KR7), 
PHAR3_MOUSE (Q8BYK5), PHAR3_RAT   (Q6RFY2), PHAR4_BOVIN (F1MCY2), 
PHAR4_CHICK (F1N8V3), PHAR4_HUMAN (Q8IZ21), PHAR4_MOUSE (Q501J7), 
PHAR4_PONAB (Q5RAU1), PHAR4_XENTR (F7EC58), PHR4A_DANRE (F1QIC4), 
PHR4A_XENLA (Q5HZA1), PHR4B_DANRE (Q6PEI3), PHR4B_XENLA (Q5XHF3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

10 PDB

2V51; 2V52; 2YJE; 2YJF; 4B1U; 4B1V; 4B1W; 4B1X; 4B1Y; 4B1Z