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ProRule PRU00674


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00674
Accession PRU00674
Dates 7-DEC-2007 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51342; COLIPASE_2
Name Colipase family
Function Colipase is a small protein of ~100 amino acids that functions as a cofactor for pancreatic lipase. It also binds to the bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor itself to the water-lipid interface. Colipases contain ten cysteines involved in five disulfide bonds.
Scope(s) Eukaryota
Metazoa
Example(s) Q91XL7 (COL_ICTTR);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
FUNCTIONColipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
SUBUNITForms a 1:1 stoichiometric complex with pancreatic lipase.
SUBCELLULAR LOCATIONSecreted.
end case
SIMILARITYBelongs to the colipase family.

Keywords [?]

Digestion
Lipid degradation
Lipid metabolism
Secreted
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0007586; Biological process:digestion
GO:0016042; Biological process:lipid catabolic process

Cross-references [?]

PROSITE PS00121; COLIPASE_1; 1;

Features [?]

From: PS51342
Key From To Description Tag Condition FTGroup
DISULFID 12 23 disulf C-x*-C 1
DISULFID 18 34 disulf C-x*-C 1
DISULFID 22 56 disulf C-x*-C 1
DISULFID 44 64 disulf C-x*-C 1
DISULFID 58 82 disulf C-x*-C 1

Additional information [?]

Size range 80-90 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]