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annotation rule: PRU00674

General rule information [?]

Accession PRU00674
Dates 7-DEC-2007 (Created)
26-SEP-2014 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51342; COLIPASE_2
Name Colipase family
Function Colipase is a small protein of ~100 amino acids that functions as a cofactor for pancreatic lipase. It also binds to the bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor itself to the water-lipid interface. Colipases contain ten cysteines involved in five disulfide bonds.

Propagated annotation [?]


Comments [?]

case <FTGroup:1>
Function Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Subunit Forms a 1:1 stoichiometric complex with pancreatic lipase.
Subcellular location Secreted.
end case

Similarity Belongs to the colipase family.

Cross-references [?]

case <FTGroup:1>
PROSITE PS00121; COLIPASE_1; 1;

Gene Ontology [?]

GO:0007586; Biological process: digestion.
GO:0016042; Biological process: lipid catabolic process.

Keywords [?]

end case

case <FTTag:disulf>
end case


Features [?]

From: PS51342
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     12     23           disulf   C-x*-C   1
DISULFID     18     34           disulf   C-x*-C   1
DISULFID     22     56           disulf   C-x*-C   1
DISULFID     44     64           disulf   C-x*-C   1
DISULFID     58     82           disulf   C-x*-C   1

Additional information [?]

Size range 80-90 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q91XL7 (COL_ICTTR)
Scope
Eukaryota; Metazoa; Vertebrata

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]