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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00674


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00674
General rule information [?]

Accession PRU00674
Dates 07-DEC-2007 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51342; COLIPASE_2
Name Colipase family
Function Colipase is a small protein of ~100 amino acids that functions as a cofactor for pancreatic lipase. It also binds to the bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor itself to the water-lipid interface. Colipases contain ten cysteines involved in five disulfide bonds.
Scope(s) Eukaryota
Metazoa
Example(s) Q91XL7;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
FUNCTIONColipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
SUBUNITForms a 1:1 stoichiometric complex with pancreatic lipase.
SUBCELLULAR LOCATIONSecreted.
end case
SIMILARITYBelongs to the colipase family.

Keywords [?]

Digestion
Lipid degradation
Lipid metabolism
Secreted
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0007586; Biological process:digestion
GO:0016042; Biological process:lipid catabolic process

Cross-references [?]

PROSITE PS00121; COLIPASE_1; 1;

Features [?]

From: PS51342
Key From To Description Tag Condition FTGroup
DISULFID 12 23 disulf C-x*-C 1
DISULFID 18 34 disulf C-x*-C 1
DISULFID 22 56 disulf C-x*-C 1
DISULFID 44 64 disulf C-x*-C 1
DISULFID 58 82 disulf C-x*-C 1

Additional information [?]

Size range 80-90 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]