We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00681
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00681
General rule information
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| Accession | PRU00681 |
| Dates | 14-MAY-2008 (Created)
13-JAN-2023 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51350; PTS_HPR_DOM |
Name | PTS HPR domain |
| Function | The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species. |
| Scope(s) |
Bacteria Archaea |
| Example(s) | P08877; |
Propagated annotation
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Keywords
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| Kinase | |
| case <Feature:PS51350:46=S> and <OC:Bacillota> | |
| Phosphoprotein | |
| end case | |
| Phosphotransferase system | |
| Transferase | |
Gene Ontology
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| GO:0009401; Biological process:phosphoenolpyruvate-dependent sugar phosphotransferase system |
| GO:0016740; Molecular function:transferase activity |
| GO:0016301; Molecular function:kinase activity |
Cross-references
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Features
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| From: PS51350 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HPr #" | |||||||||
| case <AnyFeature:PS51094:61=H> or <AnyFeature:PS51096:9=H> | ||||||||||||
| ACT_SITE | 15 | 15 | /note="Pros-phosphohistidine intermediate; for HPr activity" | H | ||||||||
| else | ||||||||||||
| ACT_SITE | 15 | 15 | /note="Pros-phosphohistidine intermediate" | H | ||||||||
| end case | ||||||||||||
| case <Feature:PS51350:46=S> and <OC:Bacillota> | ||||||||||||
| MOD_RES | 46 | 46 | /note="Phosphoserine; by HPrK/P" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 80-95 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [1] Bacteria [81] All [ 82 ]
- Retrieve set of proteins with 3D structure for this domain