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annotation rule: PRU00681

General rule information [?]

Accession PRU00681
Dates 14-MAY-2008 (Created)
13-JAN-2023 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51350; PTS_HPR_DOM
Name PTS HPR domain
Function The histidine-containing phosphocarrier protein (HPr) is a central component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species.

Propagated annotation [?]


Cross-references [?]

case <Feature:PS51350:15=H>
PROSITE PS00369; PTS_HPR_HIS; 1;
end case

case <Feature:PS51350:46=S>
PROSITE PS00589; PTS_HPR_SER; 1;
end case


Gene Ontology [?]

GO:0009401; Biological process: phosphoenolpyruvate-dependent sugar phosphotransferase system.
GO:0016740; Molecular function: transferase activity.
GO:0016301; Molecular function: kinase activity.

Keywords [?]

Kinase
case <Feature:PS51350:46=S> and <OC:Bacillota>
Phosphoprotein
end case

Phosphotransferase system
Transferase

Features [?]

From: PS51350
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HPr #        
case <AnyFeature:PS51094:61=H> or <AnyFeature:PS51096:9=H>
ACT_SITE     15     15       Pros-phosphohistidine intermediate; for HPr activity     H  
else
ACT_SITE     15     15       Pros-phosphohistidine intermediate     H  
end case

case <Feature:PS51350:46=S> and <OC:Bacillota>
MOD_RES     46     46       Phosphoserine; by HPrK/P        
end case


Additional information [?]

Size range 80-95 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P08877 (PTHP_BACSU)
Scope
Bacteria
Archaea

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]