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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01072


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01072
General rule information [?]

Accession PRU01072
Dates 29-OCT-2014 (Created)
03-JUN-2021 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51736; RECOMBINASES_3
Name Resolvase/invertase-type recombinase catalytic domain
Function The serine recombinases or resolvase/invertase family groups enzymes which share the following structural characteristics: an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA, and a C-terminal helix-turn-helix DNA-binding domain
Scope(s) Bacteria
Viruses
Archaea
Methanocaldococcus
Example(s) P19241;

Propagated annotation [?]

Keywords [?]

DNA integration
DNA recombination
end case

Gene Ontology [?]

case <FT:2>
GO:0000150; Molecular function:DNA strand exchange activity
GO:0015074; Biological process:DNA integration

Cross-references [?]

PROSITE PS00397; RECOMBINASES_1; 1;
PROSITE PS00398; RECOMBINASES_2; 1;

Features [?]

From: PS51736
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Resolvase/invertase-type recombinase catalytic #"
ACT_SITE 9 9 /note="O-(5'-phospho-DNA)-serine intermediate" S

Additional information [?]

Size range 46-171 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]