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ProRule PRU01420


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PURL: https://purl.expasy.org/prosite/rule/PRU01420
General rule information [?]

Accession PRU01420
Dates -- (Created)
-- (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52075; IFN_I
Name Interferon (IFN) type-I family
Function Type I IFNs are widespread in vertebrates from fish to mammals and include the IFN-alpha family of subtypes, a single IFN-beta and several poorly defined single gene products (IFN-epsilon, IFN-tau, IFN-kappa, IFN- omega, IFN-delta and IFN-zeta. Type I IFNs have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses
Scope(s) Eukaryota
Euteleostomi
Example(s) P01574;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted.
SIMILARITYBelongs to the type-I (or alpha/beta) interferon family.

Keywords [?]

Antiviral defense
Cytokine
Secreted
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0005125; Molecular function:cytokine activity
GO:0005615; Cellular component:extracellular space
GO:0051607; Biological process:defense response to virus

Cross-references [?]

PROSITE PS00252; INTERFERON_A_B_D; 0-1;
PROSITE PS00001; ASN_GLYCOSYLATION; 0-1;

Features [?]

From: PS52075
Key From To Description Tag Condition FTGroup
DISULFID 1 99 disulf C-x*-C
DISULFID 29 139 disulf C-x*-C
DISULFID 36 126 disulf C-x*-C
DISULFID 64 86 disulf C-x*-C

Additional information [?]

Size range 152-176 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]