To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS. To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017. From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
Cytochrome c oxidase (EC 184.108.40.206)  is an oligomeric enzymatic complex which
is a component of the respiratory chain complex and is involved in the
transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme
complex is located in the mitochondrial inner membrane; in aerobic prokaryotes
it is found in the plasma membrane. In addition to the three large subunits
that form the catalytic center of the enzyme complex there are, in eukaryotes,
a variable number of small polypeptidic subunits. One of these subunits which
is known as Vb in mammals, V in slime mold and IV in yeast, binds a zinc atom.
The sequence of subunit Vb is well conserved and includes three to four
conserved cysteines that coordinate the zinc ion [2,3]. Two of these cysteines
are clustered in the C-terminal section of the subunit; we have used this
region as a signature pattern. We also developed a profile that covers the
whole subunit Vb zinc binding region.
January 2008 / Text revised; profile added.
PROSITE methods (with tools and information) covered by this documentation:
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.