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PROSITE documentation PDOC00952

GDA1/CD39 family of nucleoside phosphatases signature


A number of nucleoside diphosphate and triphosphate hydrolases as well as some yet uncharacterized proteins have been found to belong to the same family [1,2]. This family currently consist of:

  • Yeast guanosine-diphosphatase (EC (GDPase) (gene GDA1). GDA1 is a golgi integral membrane enzyme that catalyzes the hydrolysis of GDP to GMP.
  • Potato apyrase (EC (adenosine diphosphatase) (ADPase). Apyrase acts on both ATP and ADP to produce AMP.
  • Mammalian vascular ATP-diphosphohydrolase (EC (also known as lymphoid cell activation antigen CD39).
  • Toxoplasma gondii nucleoside-triphosphatases (EC (NTPase). NTPase hydrolyses various nucleoside triphosphates to produce the corresponding nucleoside mono- and diphosphates. This enzyme is secreted into the invaded host cell into the parasitophorous vacuole, a specialized compartment where the parasite intracellulary resides.
  • Pea nucleoside-triphosphatases (EC (NTPase).
  • Caenorhabditis elegans hypothetical protein C33H5.14.
  • Caenorhabditis elegans hypothetical protein R07E4.4.
  • Yeast chromosome V hypothetical protein YER005w.

The above uncharacterized proteins all seem to be membrane-bound.

All these proteins share a number of conserved domains. We have selected the best conserved of these domains. It is located in the central section of the proteins.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

GDA1_CD39_NTPASE, PS01238; GDA1/CD39 family of nucleoside phosphatases signature  (PATTERN)


1AuthorsHanda M., Guidotti G.
TitlePurification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum).
SourceBiochem. Biophys. Res. Commun. 218:916-923(1996).
PubMed ID8579614

2AuthorsVasconcelos E.G., Ferreira S.T., de Carvalho T.M.U., de Souza W., Kettlun A.M., Mancilla M., Valenzuela M.A., Verjovski-Almeida S.
TitlePartial purification and immunohistochemical localization of ATP diphosphohydrolase from Schistosoma mansoni. Immunological cross-reactivities with potato apyrase and Toxoplasma gondii nucleoside triphosphate hydrolase.
SourceJ. Biol. Chem. 271:22139-22145(1996).
PubMed ID8703025

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