|PROSITE documentation PDOC51048
SGS domain profile
The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was
initially identified in eukaryotic SGT1 proteins . It was latter also found
in calcyclin-binding proteins . The SGS domain has been shown to bind to
proteins of the S100 family, which are thought to function as sensors of
calcium ion concentration in the cell .
Some proteins known to contain a SGS domain are listed below:
- Yeast suppressor of the G2 allele of skp1 (SGT1). It is required for cell
cycle progression at the G1/S-phase and G2/M-phase transitions. It
associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box
complex ubiquitin ligase and in kinetochore complexes.
- Arabidopsis thaliana SGT1a and SGT1b.
- Mammalian SGT1.
- Mammalian calcyclin-binding protein/Siah-1-interacting protein
(CacyBP/SIP), a component of a novel pathway of β-catenin
The profile we developed covers the entire SGS domain.
December 2004 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|SGS, PS51048; SGS domain profile (MATRIX)
|Sequences known to belong to this class detected by the profile:
|Other sequence(s) detected in Swiss-Prot:
|Matching PDB structures:
||Azevedo C., Sadanandom A., Kitagawa K., Freialdenhoven A., Shirasu K., Schulze-Lefert P.
||The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
||Nowotny M., Spiechowicz M., Jastrzebska B., Filipek A., Kitagawa K., Kuznicki J.
||Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.
||J. Biol. Chem. 278:26923-26928(2003).
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