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The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was
initially identified in eukaryotic SGT1 proteins . It was latter also found
in calcyclin-binding proteins . The SGS domain has been shown to bind to
proteins of the S100 family, which are thought to function as sensors of
calcium ion concentration in the cell .
Some proteins known to contain a SGS domain are listed below:
Yeast suppressor of the G2 allele of skp1 (SGT1). It is required for cell
cycle progression at the G1/S-phase and G2/M-phase transitions. It
associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box
complex ubiquitin ligase and in kinetochore complexes.
Arabidopsis thaliana SGT1a and SGT1b.
Mammalian calcyclin-binding protein/Siah-1-interacting protein
(CacyBP/SIP), a component of a novel pathway of β-catenin
The profile we developed covers the entire SGS domain.
December 2004 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Azevedo C., Sadanandom A., Kitagawa K., Freialdenhoven A., Shirasu K., Schulze-Lefert P.
The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
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