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The SGT1-specific (SGS) domain is a module of ~90 amino acids, which was initially identified in eukaryotic SGT1 proteins [1]. It was latter also found in calcyclin-binding proteins [2]. The SGS domain has been shown to bind to proteins of the S100 family, which are thought to function as sensors of calcium ion concentration in the cell [2].

Some proteins known to contain a SGS domain are listed below:

• Yeast suppressor of the G2 allele of skp1 (SGT1). It is required for cell cycle progression at the G1/S-phase and G2/M-phase transitions. It associates with Skp1 and regulates its function in the Skp1/Cullin1/F-box complex ubiquitin ligase and in kinetochore complexes.
• Arabidopsis thaliana SGT1a and SGT1b.
• Mammalian SGT1.
• Mammalian calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP), a component of a novel pathway of β-catenin ubiquitination.

The profile we developed covers the entire SGS domain.

December 2004 / First entry.

PROSITE method (with tools and information) covered by this documentation:

SGS, PS51048; SGS domain profile  (MATRIX)

Sequences known to belong to this class detected by the profile: ALL Other sequence(s) detected in Swiss-Prot: NONE

• Domain architecture view of Swiss-Prot proteins matching PS51048 • Retrieve an alignment of Swiss-Prot true positive hits:   Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format • Retrieve the sequence logo from the alignment • Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS51048 • Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS51048 • Scan Swiss-Prot/TrEMBL entries against PS51048 • view ligand binding statistics

Matching PDB structures: 2JTT [ALL]

1	Authors	Azevedo C., Sadanandom A., Kitagawa K., Freialdenhoven A., Shirasu K., Schulze-Lefert P.
	Title	The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
	Source	Science 295:2073-2076(2002).
	PubMed ID	11847307
	DOI	10.1126/science.1067554;

2	Authors	Nowotny M., Spiechowicz M., Jastrzebska B., Filipek A., Kitagawa K., Kuznicki J.
	Title	Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.
	Source	J. Biol. Chem. 278:26923-26928(2003).
	PubMed ID	12746458
	DOI	10.1074/jbc.M211518200;

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