Entry: PS00176

General information about the entry
Entry name TOPOISOMERASE_I_EUK
Accession number PS00176
Entry type PATTERN
Date APR-1990 (CREATED); NOV-1997 (DATA UPDATE); MAR-2013 (INFO UPDATE).
PROSITE Documentation PDOC00159
Associated ProRule PRU10130
Name and characterization of the entry
DescriptionEukaryotic DNA topoisomerase I active site.
Pattern [DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].
Numerical results
  • UniProtKB/Swiss-Prot release number: 2013_05, total number of sequence entries in that release: 540052.
  • Total number of hits in UniProtKB/Swiss-Prot: 24 hits in 24 different sequences
  • Number of hits on proteins that are known to belong to the set under consideration: 22 hits in 22 different sequences
  • Number of hits on proteins that could potentially belong to the set under consideration: 0 hits in 0 different sequences
  • Number of false hits (on unrelated proteins): 2 hits in 2 different sequences
  • Number of known missed hits: 3
  • Number of partial sequences which belong to the set under consideration, but which are not hit by the pattern or profile because they are partial (fragment) sequences: 0
  • Precision (true hits / (true hits + false positives)): 91.67 %
  • Recall (true hits / (true hits + false negatives)): 88.00 %
Comments
  • Taxonomic range: Eukaryotes, Eukaryotic viruses
  • Maximum known number of repetitions of the pattern in a single protein: 1
  • `Interesting' site in the pattern: 8,active_site
  • VERSION: 1
Cross-references
UniProtKB/Swiss-Prot True positive hits:
TOP1M_HUMAN (Q969P6), TOP1M_PANTR (A9Q1D5), TOP1_ARATH  (P30181), 
TOP1_CAEEL  (O17966), TOP1_CANAX  (Q00313), TOP1_CHLAE  (Q7YR26), 
TOP1_CRIGR  (Q07050), TOP1_DAUCA  (P93119), TOP1_DICDI  (Q54RC3), 
TOP1_DROME  (P30189), TOP1_HUMAN  (P11387), TOP1_MOUSE  (Q04750), 
TOP1_RAT    (Q9WUL0), TOP1_RFVKA  (P16472), TOP1_SCHPO  (P07799), 
TOP1_USTMA  (P41511), TOP1_VACCA  (Q76ZS7), TOP1_VACCC  (P68697), 
TOP1_VACCW  (P68698), TOP1_VAR67  (P32989), TOP1_XENLA  (P41512), 
TOP1_YEAST  (P04786)
False negative hits (sequences which belong to the set under consideration, but which have not been picked up by the pattern or profile):
TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT   (Q6IM78)
False positive hits (sequences which do not belong to the set under consideration):
L_DUGBA     (Q66431), YE88_SCHPO  (O14304)
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:

[Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format]

Retrieve the sequence logo from the alignment

PDB
[Detailed view]		 1A41; 2H7G; 3IGC;

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission

If you would like to retrieve all the Swiss-Prot entries referenced in the DR lines of this entry (with the exception of false positive hits) , you can enter a file name. These entries will then be saved to a file under this name. (Please note that this temporary file will only be kept for 1 week.)

File name:

Format: Swiss-Prot Fasta

or