Entry: PS00176

General information about the entry

Entry name [info] TOPOISOMERASE_I_EUK
Accession [info] PS00176
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); NOV-1997 (DATA UPDATE); MAY-2016 (INFO UPDATE).
PROSITE Doc. [info] PDOC00159
Associated ProRule [info] PRU10130

Name and characterization of the entry

Description [info] Eukaryotic DNA topoisomerase I active site.
Pattern [info]
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2016_06 which contains 551'385 sequence entries.


Total number of hits 24 in 24 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 91.67 %
Recall (true positives / (true positives + false negatives)) 88.00 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
22 sequences

TOP1M_HUMAN (Q969P6    ), TOP1M_PANTR (A9Q1D5    ), TOP1_ARATH  (P30181    ), 
TOP1_CAEEL  (O17966    ), TOP1_CANAX  (Q00313    ), TOP1_CHLAE  (Q7YR26    ), 
TOP1_CRIGR  (Q07050    ), TOP1_DAUCA  (P93119    ), TOP1_DICDI  (Q54RC3    ), 
TOP1_DROME  (P30189    ), TOP1_HUMAN  (P11387    ), TOP1_MOUSE  (Q04750    ), 
TOP1_RAT    (Q9WUL0    ), TOP1_RFVKA  (P16472    ), TOP1_SCHPO  (P07799    ), 
TOP1_USTMA  (P41511    ), TOP1_VACCA  (Q76ZS7    ), TOP1_VACCC  (P68697    ), 
TOP1_VACCW  (P68698    ), TOP1_VAR67  (P32989    ), TOP1_XENLA  (P41512    ), 
TOP1_YEAST  (P04786    )
» more

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

TOP1E_MIMIV (Q7T6X9    ), TOP1M_MOUSE (Q8R4U6    ), TOP1M_RAT   (Q6IM78    )

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

L_DUGBA     (Q66431    ), YE88_SCHPO  (O14304    )

		
PDB
[Detailed view]
3 PDB

1A41; 2H7G; 3IGC

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission