Entry: PS00176

General information about the entry

Entry name [info] TOPOISOMERASE_I_EUK
Accession [info] PS00176
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); NOV-1997 (DATA UPDATE); OCT-2015 (INFO UPDATE).
PROSITE Doc. [info] PDOC00159
Associated ProRule [info] PRU10130

Name and characterization of the entry

Description [info] Eukaryotic DNA topoisomerase I active site.
Pattern [info]

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2015_11 which contains 549'832 sequence entries.

Total number of hits 24 in 24 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 91.67 %
Recall (true positives / (true positives + false negatives)) 88.00 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

True positive sequences
22 sequences

TOP1M_HUMAN (Q969P6), TOP1M_PANTR (A9Q1D5), TOP1_ARATH  (P30181), 
TOP1_CAEEL  (O17966), TOP1_CANAX  (Q00313), TOP1_CHLAE  (Q7YR26), 
TOP1_CRIGR  (Q07050), TOP1_DAUCA  (P93119), TOP1_DICDI  (Q54RC3), 
TOP1_DROME  (P30189), TOP1_HUMAN  (P11387), TOP1_MOUSE  (Q04750), 
TOP1_RAT    (Q9WUL0), TOP1_RFVKA  (P16472), TOP1_SCHPO  (P07799), 
TOP1_USTMA  (P41511), TOP1_VACCA  (Q76ZS7), TOP1_VACCC  (P68697), 
TOP1_VACCW  (P68698), TOP1_VAR67  (P32989), TOP1_XENLA  (P41512), 
TOP1_YEAST  (P04786)
» more

False negative sequences
3 sequences


False positive sequences
2 sequences

L_DUGBA     (Q66431), YE88_SCHPO  (O14304)

[Detailed view]

1A41; 2H7G; 3IGC

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