Entry: PS00176

Forthcoming changes to the profile format
General information about the entry

Entry name [info] TOPOISOMERASE_I_EUK
Accession [info] PS00176
Entry type [info] PATTERN
Date [info] APR-1990 (CREATED); NOV-1997 (DATA UPDATE); SEP-2014 (INFO UPDATE).
PROSITE Doc. [info] PDOC00159
Associated ProRule [info] PRU10130

Name and characterization of the entry

Description [info] Eukaryotic DNA topoisomerase I active site.
Pattern [info]
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2014_10 which contains 546'790 sequence entries.


Total number of hits 24 in 24 different sequences
Number of true positive hits 22 in 22 different sequences
Number of 'unknown' hits
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 91.67 %
Recall (true positives / (true positives + false negatives)) 88.00 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
22 sequences

TOP1M_HUMAN (Q969P6), TOP1M_PANTR (A9Q1D5), TOP1_ARATH  (P30181), 
TOP1_CAEEL  (O17966), TOP1_CANAX  (Q00313), TOP1_CHLAE  (Q7YR26), 
TOP1_CRIGR  (Q07050), TOP1_DAUCA  (P93119), TOP1_DICDI  (Q54RC3), 
TOP1_DROME  (P30189), TOP1_HUMAN  (P11387), TOP1_MOUSE  (Q04750), 
TOP1_RAT    (Q9WUL0), TOP1_RFVKA  (P16472), TOP1_SCHPO  (P07799), 
TOP1_USTMA  (P41511), TOP1_VACCA  (Q76ZS7), TOP1_VACCC  (P68697), 
TOP1_VACCW  (P68698), TOP1_VAR67  (P32989), TOP1_XENLA  (P41512), 
TOP1_YEAST  (P04786)
» More

UniProtKB/Swiss-Prot
False negative sequences
3 sequences

TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT   (Q6IM78)

		
UniProtKB/Swiss-Prot
False positive sequences
2 sequences

L_DUGBA     (Q66431), YE88_SCHPO  (O14304)

		
PDB
[Detailed view]
3 PDB

1A41; 2H7G; 3IGC

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission