To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
annotation rule: PRU00840

General rule information [?]

Accession PRU00840
Dates 8-NOV-2010 (Created)
23-JAN-2017 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51507; IRF_2
Name IRF tryptophan pentad repeat DNA-binding domain
Function The IRF tryptophan pentad repeat DNA-binding domain has an alpha/ beta architecture comprising a cluster of three alpha-helices (alpha1-alpha3) flanked on one side by a mixed four-stranded beta-sheet (beta1-beta4). It forms a helix-turn-helix motif that binds to ISRE consensus sequences found in target promoters.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the IRF family.

Cross-references [?]

PROSITE PS00601; IRF_1; 1;

Gene Ontology [?]

GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.
GO:0005634; Cellular component: nucleus.
GO:0003677; Molecular function: DNA binding.

Keywords [?]


Features [?]

From: PS51507
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     1     107       IRF tryptophan pentad repeat        

Additional information [?]

Size range 95-128 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O14896 (IRF6_HUMAN)
Scope Eukaryota; Euteleostomi
Comments None

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]