PROSITE

Accession	PRU50000
Dates	3-DEC-2007 (Created) 7-JUN-2008 (Last updated, Version 6)

Data class

Protein

Predictors

Metamotif; -; Nter=5,15=PS50076=15,220=PS51287=0,15=PS51341=35,50=PS51206=65,150=Cter

Names

Large T antigen; LT; LT-AG

Identifier

LT

RecName: Full=Large T antigen; Short=LT; Short=LT-AG;

FUNCTION: Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication (By similarity).

SUBUNIT: Forms homohexamers in the presence of ATP (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity).

DOMAIN: The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA (By similarity).

PROSITE

PS50076; DNAJ_2; 1; trigger=PRU00286; PS51287; T_AG_OBD; 1; trigger=PRU00620; PS51341; ZF_T_AG_D1; 1; trigger=PRU00671; PS51206; SF3_HELICASE_1; 1; trigger=PRU00551;

GO:0005634; Cellular component: nucleus.

Early protein, Nucleus.

From: Nter=5,15=PS50076=15,220=PS51287=0,15=PS51341=35,50=PS51206=65,150=Cter
Key		From		To		Description		Condition		FTGroup
CHAIN		from		to		Large T antigen

Size range:	580-790 amino acids
Related UniRules:	None
Example:	Q53R41 (FAKD1_HUMAN)
Scope:	Eukaryota
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None

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