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ProRule PRU50000


General rule information [?]

Accession PRU50000
Dates 3-DEC-2007 (Created)
22-NOV-2019 (Last updated, Version 9)
Data class Protein;
Predictors Metamotif; -; Nter~5,15~PS50076~15,220~PS51287~0,15~PS51341~35,50~PS51206~65,150~Cter
Name Large T antigen
Function None
Scope(s) Eukaryota
Example(s) Q53R41 (FAKD1_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LT
Protein name RecName: Full=Large T antigen;
                 Short=LT;
                 Short=LT-AG;

Comments [?]

FUNCTIONInitiates DNA unwinding and replication via elaborate interactions with the viral origin of replication.
SUBUNITForms homohexamers in the presence of ATP.
SUBCELLULAR LOCATIONNucleus.
DOMAINThe zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA.

Keywords [?]


Gene Ontology [?]

GO:0005634; Cellular component:nucleus

Cross-references [?]

PROSITE PS50076; DNAJ_2; 1;
PROSITE PS51287; T_AG_OBD; 1;
PROSITE PS51341; ZF_T_AG_D1; 1;
PROSITE PS51206; SF3_HELICASE_1; 1;

Features [?]

From: any
Key From To Description Tag Condition FTGroup
CHAIN from to /note="Large T antigen"

Additional information [?]

Size range 580-790 amino acids
Related rules None
Fusion Nter: None Cter: None
Repeats None
Topology None

Copyright

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