PROSITE documentation PDOC00806YjeF C-terminal domain signatures and profile
The YjeF C-terminal domain is an ~280-residue module found in the following proteins:
- Yeast chromosome XI hypothetical protein YKL151c.
- Caenorhabditis elegans hypothetical protein R107.2.
- Escherichia coli hypothetical protein YjeF.
- Bacillus subtilis hypothetical protein yxkO.
- Helicobacter pylori hypothetical protein HP1363.
- Mycobacterium tuberculosis hypothetical protein MtCY77.05c.
- Mycobacterium leprae hypothetical protein B229_C2_201.
- Synechocystis strain PCC 6803 hypothetical protein sll1433.
- Methanococcus jannaschii hypothetical protein MJ1586.
- Streptococcus mutans putative uncharacterized protein SMU.573.
- Streptococcus thermophilus predicted sugar kinase STER_0661.
- Streptococcus sanguinis putative uncharacterized protein SSA_0673.
- Thermotoga maritima hypothetical protein Tm0922.
The YjeF C-terminal domain has an α/β fold and shows high structural homology to the members of a ribokinase-like superfamily. The members of the ribokinase-like superfamily are all phosphotransferases and catalyze the phosphorylation of the hydroxymethyl group of the substrate; magnesium and ATP (or ADP) are required for their activity. The YjeF C-terminal is found in association with the YjeF N-terminal domain, which belongs of a specialized family of Rossmann fold domains (see <PDOC51385>) [1,2,3].
The first pattern we developed covers residues that might be involved in forming the substrate-binding pocket. The second one corresponds to residues that could form a kinase anion hole, with the conserved aspartate predicted to be the catalytic base [1]. We also developed a profile which covers the entire YjeF C-terminal domain.
Last update:May 2008 / Text revised; profile added.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Zhang R.-G. Grembecka J. Vinokour E. Collart F. Dementieva I. Minor W. Joachimiak A. |
| Title | Structure of Bacillus subtilis YXKO--a member of the UPF0031 family and a putative kinase. | |
| Source | J. Struct. Biol. 139:161-170(2002). | |
| PubMed ID | 12457846 |
| 2 | Authors | Zhou Y.-F. Li L.-F. Yang C. Liang Y.-H. Su X.-D. |
| Title | Preliminary X-ray crystallographic analysis of SMU.573, a putative sugar kinase from Streptococcus mutans. | |
| Source | Acta Crystallogr. F 64:47-49(2008). | |
| PubMed ID | 18097102 | |
| DOI | 10.1107/S1744309107065645 |
| 3 | Authors | Anantharaman V. Aravind L. |
| Title | Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. | |
| Source | BMC Genomics 5:45-45(2004). | |
| PubMed ID | 15257761 | |
| DOI | 10.1186/1471-2164-5-45 |
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