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PROSITE documentation PDOC00876

Bacterial microcompartiments proteins signature


A family of small bacterial proteins has been recently discovered [1,2] that seem to be involved in the formation of specific microcompartiments in the cell in which the metabolism of potentially toxic by-products takes place. The proteins that belong to this family are:

  • Escherichia coli and Salmonella typhimurium cchA, involved in the degradation of ethanolamine.
  • Salmonella typhimurium pduA, involved in 1,2-propanediol metabolism.
  • Synechococcus ccmK, involved in the formation of the carboxysome which is a polyhedral inclusion where RuBisCO is sequestred.
  • Thiobacillus neapolitanus carboxysome shell proteins csoS1A, csoS1B and csoS1C.
  • A number of hypothetical Synechococcus proteins which are also probably involved in the carboxysome shell formation.
  • Escherichia coli hypothetical protein yffI.

These proteins have from 90 to 120 amino acid residues with the exception of two Synechococcus hypothetical proteins which contains respectively 275 and 297 amino acids and which are made up of two tandem homologous domains. As a signature pattern, we selected a conserved region in their N-terminal section.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BACT_MICROCOMP, PS01139; Bacterial microcompartiments proteins signature  (PATTERN)


1AuthorsEnglish R.S. Lorbach S.C. Qin X. Shively J.M.
TitleIsolation and characterization of a carboxysome shell gene from Thiobacillus neapolitanus.
SourceMol. Microbiol. 12:647-654(1994).
PubMed ID7934888

2AuthorsStojiljkovic I. Bauemler A.J. Heffron F.
TitleEthanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster.
SourceJ. Bacteriol. 177:1357-1366(1995).
PubMed ID7868611

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