PROSITE documentation PDOC51226TEP1 N-terminal repeat profile
Telomerase protein component 1 (TP1/TLP1) or TEP1 is a protein component of two ribonucleoprotein (RNP) complexes: vaults and telomerase. Vaults are large RNP particles with a barrel-like structure (see <PDOC51224>). The telomerase RNP replenishes incomplete chromosome termini due to DNA replication. Mammalian TEP1 is an RNA-binding protein and is required for the association of vault RNA with the vault particle [1,2]. The N-terminal part of TEP1 contains 4 copies of the TEP1 N-terminal repeat in tandem. The repeat is composed of 30 amino acids and occurs in combination with the TROVE (see <PDOC50988>) and NACHT (see <PDOC50837>) domains and with WD-40 repeats (see <PDOC00574>) in the C-terminal part.
The profile we developed covers the entire TEP1 N-terminal repeat.
Last update:July 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kickhoefer V.A. Liu Y. Kong L.B. Snow B.E. Stewart P.L. Harrington L. Rome L.H. |
| Title | The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. | |
| Source | J. Cell Biol. 152:157-164(2001). | |
| PubMed ID | 11149928 |
| 2 | Authors | Poderycki M.J. Rome L.H. Harrington L. Kickhoefer V.A. |
| Title | The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. | |
| Source | Nucleic Acids Res. 33:893-902(2005). | |
| PubMed ID | 15701761 | |
| DOI | 10.1093/nar/gki234 |
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