The MIB/HERC2 domain is a conserved region of ~80 amino acids, which has been
Animal Mind bomb 1 and 2 (MIB1 and MIB2) E3 ubiquitin ligases. They contain
a very similar domain organization including an amino terminus ZZ-type zinc
finger (see <PDOC50135>) surrounded by two MIB/HERC2 domains, followed by
two MIB specific repeats, multiple ankyrin repeats (see <PDOC50088>), and
two or more Ring fingers (see <PDOC00449>) at their C-terminal ends. They
partake in the Notch signaling pathway by ubiquitinating the Notch
receptors Delta and Jagged prior to endocytosis [1,2,3,4].
Animal probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-). It contains
additional motifs, including RCC1 repeats (see <PDOC00544>), a DOC domain
(see <PDOC51284>), a carboxy-terminal HECT domain (see <PDOC50237>), and a
ZZ-type zinc finger .
The profile we developed covers the entire MIB/HERC2 domain.
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