PROSITE documentation PDOC51416
MIB/HERC2 domain profile


The MIB/HERC2 domain is a conserved region of ~80 amino acids, which has been identified in:

  • Animal Mind bomb 1 and 2 (MIB1 and MIB2) E3 ubiquitin ligases. They contain a very similar domain organization including an amino terminus ZZ-type zinc finger (see <PDOC50135>) surrounded by two MIB/HERC2 domains, followed by two MIB specific repeats, multiple ankyrin repeats (see <PDOC50088>), and two or more Ring fingers (see <PDOC00449>) at their C-terminal ends. They partake in the Notch signaling pathway by ubiquitinating the Notch receptors Delta and Jagged prior to endocytosis [1,2,3,4].
  • Animal probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-). It contains additional motifs, including RCC1 repeats (see <PDOC00544>), a DOC domain (see <PDOC51284>), a carboxy-terminal HECT domain (see <PDOC50237>), and a ZZ-type zinc finger [5].

The profile we developed covers the entire MIB/HERC2 domain.

Last update:

December 2008 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MIB_HERC2, PS51416; MIB/HERC2 domain profile  (MATRIX)


1AuthorsItoh M. Kim C.-H. Palardy G. Oda T. Jiang Y.-J. Maust D. Yeo S.-Y. Lorick K. Wright G.J. Ariza-McNaughton L. Weissman A.M. Lewis J. Chandrasekharappa S.C. Chitnis A.B.
TitleMind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.
SourceDev. Cell 4:67-82(2003).
PubMed ID12530964

2AuthorsKoo B.-K. Yoon K.-J. Yoo K.-W. Lim H.-S. Song R. So J.-H. Kim C.-H.
TitleKong Y.-Y. Mind bomb-2 is an E3 ligase for Notch ligand.
SourceJ. Biol. Chem. 280:22335-22342(2005).
PubMed ID15824097

3AuthorsBarsi J.C. Rajendra R. Wu J.I. Artzt K.
TitleMind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
SourceMech. Dev. 122:1106-1117(2005).
PubMed ID16061358

4AuthorsWu J.I. Rajendra R. Barsi J.C. Durfee L. Benito E. Gao G. Kuruvilla M. Hrdlickova R. Liss A.S. Artzt K.
TitleTargeted disruption of Mib2 causes exencephaly with a variable penetrance.
SourceGenesis 45:722-727(2007).
PubMed ID17987667

5AuthorsJi Y. Rebert N.A. Joslin J.M. Higgins M.J. Schultz R.A. Nicholls R.D.
TitleStructure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human.
SourceGenome Res. 10:319-329(2000).
PubMed ID10720573

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