PROSITE documentation PDOC51416MIB/HERC2 domain profile
Description
The MIB/HERC2 domain is a conserved region of ~80 amino acids, which has been identified in:
- Animal Mind bomb 1 and 2 (MIB1 and MIB2) E3 ubiquitin ligases. They contain a very similar domain organization including an amino terminus ZZ-type zinc finger (see <PDOC50135>) surrounded by two MIB/HERC2 domains, followed by two MIB specific repeats, multiple ankyrin repeats (see <PDOC50088>), and two or more Ring fingers (see <PDOC00449>) at their C-terminal ends. They partake in the Notch signaling pathway by ubiquitinating the Notch receptors Delta and Jagged prior to endocytosis [1,2,3,4].
- Animal probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-). It contains additional motifs, including RCC1 repeats (see <PDOC00544>), a DOC domain (see <PDOC51284>), a carboxy-terminal HECT domain (see <PDOC50237>), and a ZZ-type zinc finger [5].
The profile we developed covers the entire MIB/HERC2 domain.
Last update:December 2008 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Itoh M. Kim C.-H. Palardy G. Oda T. Jiang Y.-J. Maust D. Yeo S.-Y. Lorick K. Wright G.J. Ariza-McNaughton L. Weissman A.M. Lewis J. Chandrasekharappa S.C. Chitnis A.B. |
| Title | Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. | |
| Source | Dev. Cell 4:67-82(2003). | |
| PubMed ID | 12530964 |
| 2 | Authors | Koo B.-K. Yoon K.-J. Yoo K.-W. Lim H.-S. Song R. So J.-H. Kim C.-H. |
| Title | Kong Y.-Y. Mind bomb-2 is an E3 ligase for Notch ligand. | |
| Source | J. Biol. Chem. 280:22335-22342(2005). | |
| PubMed ID | 15824097 | |
| DOI | 10.1074/jbc.M501631200 |
| 3 | Authors | Barsi J.C. Rajendra R. Wu J.I. Artzt K. |
| Title | Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. | |
| Source | Mech. Dev. 122:1106-1117(2005). | |
| PubMed ID | 16061358 | |
| DOI | 10.1016/j.mod.2005.06.005 |
| 4 | Authors | Wu J.I. Rajendra R. Barsi J.C. Durfee L. Benito E. Gao G. Kuruvilla M. Hrdlickova R. Liss A.S. Artzt K. |
| Title | Targeted disruption of Mib2 causes exencephaly with a variable penetrance. | |
| Source | Genesis 45:722-727(2007). | |
| PubMed ID | 17987667 | |
| DOI | 10.1002/dvg.20349 |
| 5 | Authors | Ji Y. Rebert N.A. Joslin J.M. Higgins M.J. Schultz R.A. Nicholls R.D. |
| Title | Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. | |
| Source | Genome Res. 10:319-329(2000). | |
| PubMed ID | 10720573 |
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