We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51416MIB/HERC2 domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51416
Description
The MIB/HERC2 domain is a conserved region of ~80 amino acids, which has been identified in:
- Animal Mind bomb 1 and 2 (MIB1 and MIB2) E3 ubiquitin ligases. They contain a very similar domain organization including an amino terminus ZZ-type zinc finger (see <PDOC50135>) surrounded by two MIB/HERC2 domains, followed by two MIB specific repeats, multiple ankyrin repeats (see <PDOC50088>), and two or more Ring fingers (see <PDOC00449>) at their C-terminal ends. They partake in the Notch signaling pathway by ubiquitinating the Notch receptors Delta and Jagged prior to endocytosis [1,2,3,4].
- Animal probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-). It contains additional motifs, including RCC1 repeats (see <PDOC00544>), a DOC domain (see <PDOC51284>), a carboxy-terminal HECT domain (see <PDOC50237>), and a ZZ-type zinc finger [5].
The profile we developed covers the entire MIB/HERC2 domain.
Last update:December 2008 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Itoh M. Kim C.-H. Palardy G. Oda T. Jiang Y.-J. Maust D. Yeo S.-Y. Lorick K. Wright G.J. Ariza-McNaughton L. Weissman A.M. Lewis J. Chandrasekharappa S.C. Chitnis A.B. |
| Title | Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. | |
| Source | Dev. Cell 4:67-82(2003). | |
| PubMed ID | 12530964 |
| 2 | Authors | Koo B.-K. Yoon K.-J. Yoo K.-W. Lim H.-S. Song R. So J.-H. Kim C.-H. |
| Title | Kong Y.-Y. Mind bomb-2 is an E3 ligase for Notch ligand. | |
| Source | J. Biol. Chem. 280:22335-22342(2005). | |
| PubMed ID | 15824097 | |
| DOI | 10.1074/jbc.M501631200 |
| 3 | Authors | Barsi J.C. Rajendra R. Wu J.I. Artzt K. |
| Title | Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. | |
| Source | Mech. Dev. 122:1106-1117(2005). | |
| PubMed ID | 16061358 | |
| DOI | 10.1016/j.mod.2005.06.005 |
| 4 | Authors | Wu J.I. Rajendra R. Barsi J.C. Durfee L. Benito E. Gao G. Kuruvilla M. Hrdlickova R. Liss A.S. Artzt K. |
| Title | Targeted disruption of Mib2 causes exencephaly with a variable penetrance. | |
| Source | Genesis 45:722-727(2007). | |
| PubMed ID | 17987667 | |
| DOI | 10.1002/dvg.20349 |
| 5 | Authors | Ji Y. Rebert N.A. Joslin J.M. Higgins M.J. Schultz R.A. Nicholls R.D. |
| Title | Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. | |
| Source | Genome Res. 10:319-329(2000). | |
| PubMed ID | 10720573 |
Copyright
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