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PROSITE documentation PDOC51849

RsgI N-terminal anti-sigma domain profile





Description

Bacterial response to transient stresses is mediated largely through transcription of relevant genes directed by sigma factors. Some of the stress-responding sigma genes are associated with anti-sigma factor genes, whose products inhibit the activity of sigma factors through direct binding, which is disrupted upon stress through phosphorylation by anti-anti-sigma factors or digestion by endogenous proteases. The Bacillus subtilis bicistronic operon sigI-rsgI encodes for an alternative sigma(I) factor and its cognate anti-sigma(I) regulator RsgI that is functionally regulated by an extracytoplasmic signal. Interaction of the ~50- to ~60-residue N-terminal intracellular domain of the transmembrane protein RsgI with SigI sequesters and inactivates SigI on the inner surface of the cytoplasmic membrane. Homologues of SigI and RsgI are found in many species of the phylum Firmicutes. The extracellular modules of these RsgI-like proteins appear to have polysaccharide-related functions, and include carbohydrate-binding modules (e.g., CBM3 (see <PDOC51172>), CBM42), sugar-binding elements (e.g., PA14 (see <PDOC51820>)), and a glycoside hydrolase family 10 (GH10) (see <PDOC00510>) module [1,2,3,4].

The profile we developed covers the entire RsgI N-terminal anti-sigma domain.

Last update:

November 2017 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

RSGI_N, PS51849; RsgI N-terminal anti-sigma domain profile  (MATRIX)


References

1AuthorsAsai K. Ootsuji T. Obata K. Matsumoto T. Fujita Y. Sadaie Y.
TitleRegulatory role of RsgI in sigI expression in Bacillus subtilis.
SourceMicrobiology 153:92-101(2007).
PubMed ID17185538
DOI10.1099/mic.0.29239-0

2AuthorsKahel-Raifer H. Jindou S. Bahari L. Nataf Y. Shoham Y. Bayer E.A. Borovok I. Lamed R.
TitleThe unique set of putative membrane-associated anti-sigma factors in Clostridium thermocellum suggests a novel extracellular carbohydrate-sensing mechanism involved in gene regulation.
SourceFEMS Microbiol. Lett. 308:84-93(2010).
PubMed ID20487018
DOI10.1111/j.1574-6968.2010.01997.x

3AuthorsNataf Y. Bahari L. Kahel-Raifer H. Borovok I. Lamed R. Bayer E.A. Sonenshein A.L. Shoham Y.
TitleClostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors.
SourceProc. Natl. Acad. Sci. U.S.A. 107:18646-18651(2010).
PubMed ID20937888
DOI10.1073/pnas.1012175107

4AuthorsLiu T.-Y. Chu S.-H. Hu Y.-N. Wang J.-J. Shaw G.-C.
TitleGenetic evidence that multiple proteases are involved in modulation of heat-induced activation of the sigma factor SigI in Bacillus subtilis.
SourceFEMS Microbiol. Lett. 364:0-0(2017).
PubMed ID28333276
DOI10.1093/femsle/fnx054



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