We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00539
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00539
General rule information
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| Accession | PRU00539 |
| Dates | 16-MAR-2006 (Created)
20-MAR-2025 (Last updated, Version 14) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50507; RDRP_SSRNA_POS PROSITE; PS50522; RDRP_PHAGE PROSITE; PS50523; RDRP_DSRNA_REO PROSITE; PS50524; RDRP_DSRNA_BIR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG PROSITE; PS50526; RDRP_SSRNA_NEG_NONSEG |
Name | RdRp |
| Function | RNA-directed RNA polymerase. |
| Scope(s) |
Viruses |
| Example(s) | P24658; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=RNA-directed RNA polymerase; EC=2.7.7.48; |
Comments
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| FUNCTION | RNA-directed RNA polymerase. |
| CATALYTIC ACTIVITY | Reaction=RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate; Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA- COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; |
Keywords
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| Nucleotide-binding |
| Nucleotidyltransferase |
| Viral RNA replication |
| RNA-directed RNA polymerase |
| Transferase |
Gene Ontology
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| GO:0000166; Molecular function:nucleotide binding |
| GO:0016779; Molecular function:nucleotidyltransferase activity |
| GO:0003968; Molecular function:RNA-directed RNA polymerase activity |
| GO:0003723; Molecular function:RNA binding |
| GO:0016740; Molecular function:transferase activity |
Features
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| From: any | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="RdRp catalytic #" | |||||||||
Additional information
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| Size range | 90-230 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [505] All [ 505 ]
- Retrieve set of proteins with 3D structure for this domain