To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
PROSITE documentation PDOC00773 [for PROSITE entry PS01011]

Folylpolyglutamate synthase signatures





Description

Folylpolyglutamate synthase (EC 6.3.2.17) (FPGS) [1] is the enzyme of folate metabolism that catalyzes ATP-dependent addition of glutamate moieties to tetrahydrofolate.

Its sequence is moderately conserved between prokaryotes (gene folC) and eukaryotes. We developed two signature patterns based on the conserved regions which are rich in glycine residues and could play a role in the catalytical activity and/or in substrate binding.

Last update:

December 2004 / Patterns and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

FOLYLPOLYGLU_SYNT_1, PS01011; Folylpolyglutamate synthase signature 1  (PATTERN)

FOLYLPOLYGLU_SYNT_2, PS01012; Folylpolyglutamate synthase signature 2  (PATTERN)


Reference

1AuthorsShane B., Garrow T., Brenner A., Chen L., Choi Y.J., Hsu J.C., Stover P.
TitleFolylpoly-gamma-glutamate synthetase.
SourceAdv. Exp. Med. Biol. 338:629-634(1993).
PubMed ID8304196



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)